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FutureNeuro is the Research Ireland Centre for Translational Brain Science.  

Our VISION is to Enable people with Neurological Disorders to Live Independently

Our MISSION is Faster diagnosis, Personalized Treatments and Patient-Centered Care

We are committed to transforming the patient journey by conducting research that prioritises the needs of both patients and healthcare professionals. Our work focuses on developing advanced diagnostic tools, therapies to repair damaged brain networks, and innovative technologies that empower patients to monitor their own health, all integrated with Ireland’s national imaging, diagnostics, and digital health infrastructure. 

As a collaborative research hub, we bring together expertise across multiple disciplines and institutions, partnering with industry leaders, patient organisations, and clinical networks to drive transformative changes in healthcare. Our research spans both preclinical and clinical domains, addressing critical challenges in the diagnosis of brain conditions, precision therapies, and leveraging genomics and data science to advance treatment outcomes. 

FutureNeuro conducts research across three thematic areas:

(1) Diagnostics: we leverage the genetically homogenous nature of the Irish population to establish a large, stratified, and research-engaged patient population, enabling faster and more accurate diagnosis, the discovery of biomarkers for precision medicine, and a robust environment for clinical trials. Our work focuses on integrating genomic diagnostics into clinical care, identifying novel genetic predictors of disease, discovering and validating circulating and digital biomarkers, and advancing point-of-care testing technologies.

(2) Therapeutics: we explore new types of therapies, including molecules that work by controlling the activity of gene networks to stabilise or recover, while exploring effective ways to deliver these to the brain. For our most advanced discoveries, we focus on translating therapies from preclinical development to clinical trials, optimizing drug delivery, and refining our understanding of drug mechanisms to correct brain network dysfunction. Our ultimate goal is to advance precision medicine, ensuring targeted and effective treatments for neurological conditions.

(3) In Digital Health: we work closely with clinical partners to develop trustworthy, patient-informed, and ethical approaches for collecting and integrating data from multiple sources, including electronic health records and wearable devices. By applying advanced analytics, we extract meaningful insights to streamline clinical decision-making and improve patient outcomes. Additionally, we co-create digital health solutions that empower self-care and strengthen the patient-clinician relationship, driving more personalized and effective healthcare. 

Our research program, initially centred on diagnostics, therapeutics, and digital health for epilepsy and ALS, now extends beyond these boundaries. We are advancing research in neurodevelopmental disorders, multiple sclerosis (MS), Parkinson’s disease (PD), traumatic brain injury (TBI) and addressing significant comorbid aspects, including psychosis and mental health. 

Host Institution 

RCSI University of Medicine and Health Sciences

Professor David Henshall is a Professor of Molecular Physiology and Neuroscience at RCSI and Director of the FutureNeuro Centre. His research is centred on understanding the causes, mechanisms, and treatments for epilepsy, with a particular focus on epigenetics, non-coding RNA, and innovative therapeutics. 

David has led several major research initiatives, including the EU FP7-funded EpiMiRNA project, which aimed to uncover the role of microRNAs in epilepsy and open up new diagnostic and therapeutic pathways. His work in this field has resulted in several patents and ongoing collaborations with industry partners to advance microRNA-based therapies for epilepsy. His research also explores the patho-mechanisms underlying epilepsy following brain injury, neonatal seizures, and the development of novel medications. 

A prominent leader in the global epilepsy community, David has held numerous influential roles within the International League Against Epilepsy (ILAE), including Chair of the Neurobiology Commission (2021-2025) and Co-Chair of the Climate Change Commission Task Force. He is also a Steward for the Epilepsy Benchmarks Committee, contributing to the strategic direction of global epilepsy research, Editor-in-Chief for Pharmacology at the International Journal of Physiology, Pathophysiology & Pharmacology and past-President of Neuroscience Ireland. In 2024, David’s exceptional contributions to neuroscience were recognised with his election to the Royal Irish Academy. 

David has authored over 250 peer-reviewed publications and book chapters, and he is the author of Fine-Tuning Life: A Guide to microRNAs, Your Genome's Master Regulators, which brings the science of microRNAs to a broader audience. 

At FutureNeuro, David has championed the involvement of people with epilepsy and their families in the research process. He established a dedicated Patient & Public Involvement (PPI) Strategy and created PPI Panels within the Centre, ensuring that the voices of those affected by epilepsy help shape the direction of scientific research and innovation. 

  • Prof Gianpiero Cavalleri, RCSI University of Medicine and Health Sciences 
  • Prof Robert Forster, Dublin City University 
  • Prof Jochen Prehn, RCSI University of Medicine and Health Sciences 
  • Prof Orla Hardiman, Trinity College Dublin 
  • Prof Matthew Campbell, Trinity College Dublin 
  • Prof Colin Doherty, Trinity College Dublin 
  • Prof Sanbing Shen, University of Galway 
  • Prof David Cotter, RCSI University of Medicine and Health Sciences 
  • Prof Kathleen Bennett, RCSI University of Medicine and Health Sciences 
  • Prof Lorna Lopez, Maynooth University 
  • Prof Mary Cannon, RCSI University of Medicine and Health Sciences 
  • Prof Norman Delanty, RCSI University of Medicine and Health Sciences 
  • Prof Catherine Mooney, University College Dublin 

Key Contact Details

Prof David Henshall
Director

dhenshall@rcsi.ie

Bridget Doyle
Centre manager

bridgetdoyle@rcsi.ie

Lyndsey Butterworth
Education and Public Engagement Lead

lyndseybutterworth@rcsi.ie